2JSM
MONOMERIC HUMAN TELOMERE DNA TETRAPLEX WITH 3+1 STRAND FOLD TOPOLOGY, TWO EDGEWISE LOOPS AND DOUBLE-CHAIN REVERSAL LOOP, NMR, 10 STRUCTURES, Form 1 Natural
Summary for 2JSM
| Entry DOI | 10.2210/pdb2jsm/pdb |
| Related | 143D 186D 1K8P 2AQY 2JSK 2JSL 2JSQ |
| Descriptor | HUMAN TELOMERE DNA (1 entity in total) |
| Functional Keywords | g-tetrad; 3+1 strand folding;edgewise, double-chain reversal loops; natural form 1, 10 structures, dna |
| Total number of polymer chains | 1 |
| Total formula weight | 7287.69 |
| Authors | Kuryavyi, V.V.,Phan, A.T.,Luu, K.N.,Patel, D.J. (deposition date: 2007-07-09, release date: 2008-07-08, Last modification date: 2024-05-29) |
| Primary citation | Phan, A.T.,Kuryavyi, V.,Luu, K.N.,Patel, D.J. Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution Nucleic Acids Res., 35:6517-6525, 2007 Cited by PubMed Abstract: Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K(+) solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds. PubMed: 17895279DOI: 10.1093/nar/gkm706 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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