2JSL

Monomeric Human Telomere DNA Tetraplex with 3+1 Strand Fold Topology, Two Edgewise Loops and Double-Chain Reversal Loop, Form 2 Natural, NMR, 10 Structures

2JSL の概要

• エントリーDOI: 10.2210/pdb2jsl/pdb
• 関連するPDBエントリー: 143D 186D 1K8P 2AQY 2JSK 2JSQ
• 分子名称: HUMAN TELOMERE DNA (1 entity in total)
• 機能のキーワード: g-tetrad, 3+1 strand folding, edgewise, double-chain reversal loops, 10 structures, form 2 natural, dna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7896.08

構造登録者

Kuryavyi, V.V.,Phan, A.T.,Luu, K.N.,Patel, D.J. (登録日: 2007-07-08, 公開日: 2008-07-15, 最終更新日: 2024-05-29)

主引用文献

Phan, A.T.,Kuryavyi, V.,Luu, K.N.,Patel, D.J.
Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution.
Nucleic Acids Res., 35:6517-6525, 2007

PubMed Abstract: Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K(+) solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds.

PubMed: 17895279
DOI: 10.1093/nar/gkm706

実験手法

SOLUTION NMR