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2JOM

NMR structure of rabbit prion protein mutation I214V

2JOM の概要
エントリーDOI10.2210/pdb2jom/pdb
NMR情報BMRB: 15399
分子名称Major prion protein (1 entity in total)
機能のキーワードprion protein, unknown function
由来する生物種Oryctolagus cuniculus (rabbit)
細胞内の位置Cell membrane; Lipid-anchor, GPI-anchor: Q95211
タンパク質・核酸の鎖数1
化学式量合計16983.91
構造登録者
Li, J.,Lin, D. (登録日: 2007-03-14, 公開日: 2008-01-29, 最終更新日: 2023-12-20)
主引用文献Wen, Y.,Li, J.,Xiong, M.,Peng, Y.,Yao, W.,Hong, J.,Lin, D.
Solution Structure and Dynamics of the I214V Mutant of the Rabbit Prion Protein.
Plos One, 5:e13273-e13273, 2010
Cited by
PubMed Abstract: The conformational conversion of the host-derived cellular prion protein (PrP(C)) into the disease-associated scrapie isoform (PrP(Sc)) is responsible for the pathogenesis of transmissible spongiform encephalopathies (TSEs). Various single-point mutations in PrP(C)s could cause structural changes and thereby distinctly influence the conformational conversion. Elucidation of the differences between the wild-type rabbit PrP(C) (RaPrP(C)) and various mutants would be of great help to understand the ability of RaPrP(C) to be resistant to TSE agents.
PubMed: 20949107
DOI: 10.1371/journal.pone.0013273
主引用文献が同じPDBエントリー
実験手法
SOLUTION NMR
構造検証レポート
Validation report summary of 2jom
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-11-06に公開中

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