2JOM
NMR structure of rabbit prion protein mutation I214V
2JOM の概要
エントリーDOI | 10.2210/pdb2jom/pdb |
NMR情報 | BMRB: 15399 |
分子名称 | Major prion protein (1 entity in total) |
機能のキーワード | prion protein, unknown function |
由来する生物種 | Oryctolagus cuniculus (rabbit) |
細胞内の位置 | Cell membrane; Lipid-anchor, GPI-anchor: Q95211 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 16983.91 |
構造登録者 | |
主引用文献 | Wen, Y.,Li, J.,Xiong, M.,Peng, Y.,Yao, W.,Hong, J.,Lin, D. Solution Structure and Dynamics of the I214V Mutant of the Rabbit Prion Protein. Plos One, 5:e13273-e13273, 2010 Cited by PubMed Abstract: The conformational conversion of the host-derived cellular prion protein (PrP(C)) into the disease-associated scrapie isoform (PrP(Sc)) is responsible for the pathogenesis of transmissible spongiform encephalopathies (TSEs). Various single-point mutations in PrP(C)s could cause structural changes and thereby distinctly influence the conformational conversion. Elucidation of the differences between the wild-type rabbit PrP(C) (RaPrP(C)) and various mutants would be of great help to understand the ability of RaPrP(C) to be resistant to TSE agents. PubMed: 20949107DOI: 10.1371/journal.pone.0013273 主引用文献が同じPDBエントリー |
実験手法 | SOLUTION NMR |
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