2JII

Structure of vaccinia related kinase 3

2JII の概要

• エントリーDOI: 10.2210/pdb2jii/pdb
• 分子名称: SERINE/THREONINE-PROTEIN KINASE VRK3 MOLECULE: VACCINIA RELATED KINASE 3, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: transferase, pseudo kinase domain, vaccinia related kinase, serine/threonine-protein kinase, vrk3, kinase, atp-binding, nucleotide-binding
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : Q8IV63
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 80113.50

構造登録者

Bunkoczi, G.,Eswaran, J.,Pike, A.C.W.,Uppenberg, J.,Ugochukwu, E.,von Delft, F.,Cooper, C.,Salah, E.,Savitsky, P.,Burgess-Brown, N.,Keates, T.,Fedorov, O.,Sobott, F.,Arrowsmith, C.H.,Edwards, A.,Sundstrom, M.,Weigelt, J.,Knapp, S. (登録日: 2007-06-28, 公開日: 2007-07-10, 最終更新日: 2018-02-28)

• 主引用文献: Scheeff, E.D.,Eswaran, J.,Bunkoczi, G.,Knapp, S.,Manning, G.; Structure of the pseudokinase VRK3 reveals a degraded catalytic site, a highly conserved kinase fold, and a putative regulatory binding site.; Structure, 17:128-138, 2009; PubMed: 19141289; DOI: 10.1016/j.str.2008.10.018

実験手法

X-RAY DIFFRACTION (2 Å)