2JHB
CORE BINDING FACTOR BETA
Summary for 2JHB
| Entry DOI | 10.2210/pdb2jhb/pdb |
| Descriptor | PROTEIN (CORE BINDING FACTOR BETA) (1 entity in total) |
| Functional Keywords | core binding factor, transcription factor, gene regulation |
| Biological source | Mus musculus (house mouse) |
| Total number of polymer chains | 1 |
| Total formula weight | 16757.78 |
| Authors | Huang, X.,Peng, J.,Speck, N.A.,Bushweller, J.H. (deposition date: 1999-03-17, release date: 1999-07-05, Last modification date: 2023-12-27) |
| Primary citation | Huang, X.,Peng, J.W.,Speck, N.A.,Bushweller, J.H. Solution structure of core binding factor beta and map of the CBF alpha binding site. Nat.Struct.Biol., 6:624-627, 1999 Cited by PubMed Abstract: The core binding factor beta subunit (CBF beta) is the non-DNA binding subunit of the core-binding factors, transcription factors essential for multiple developmental processes including hematopoiesis and bone development. Chromosomal translocations involving the human CBFB gene are associated with a large percentage of human leukemias. The N-terminal 141 amino acids of CBF beta contains the heterodimerization domain for the DNA-binding CBF alpha subunits, and is sufficient for CBF beta function in vivo. Here we present the high-resolution solution structure of the CBF beta heterodimerization domain. It is a novel alpha/beta structure consisting of two three-stranded beta-sheets packed on one another in a sandwich arrangement, with four peripheral alpha-helices. The CBF alpha binding site on CBF beta has been mapped by chemical shift perturbation analysis. PubMed: 10404216DOI: 10.1038/10670 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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