2JHA

The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line

Summary for 2JHA

Entry DOI	10.2210/pdb2jha/pdb
Related	2JH9 2JHC 2JHP
Descriptor	VP4 CORE PROTEIN, DIGUANOSINE-5'-TRIPHOSPHATE, GUANINE (3 entities in total)
Functional Keywords	guanylyltransferase, viral capping enzyme, core protein, virion protein, methyltransferase, viral protein
Biological source	BLUETONGUE VIRUS 10 (ISOLATE USA)
Cellular location	Virion : P07132
Total number of polymer chains	1
Total formula weight	76592.37
Authors	Sutton, G.,Grimes, J.M.,Stuart, D.I.,Roy, P. (deposition date: 2007-02-21, release date: 2007-04-10, Last modification date: 2024-05-08)
Primary citation	Sutton, G.,Grimes, J.M.,Stuart, D.I.,Roy, P. Bluetongue Virus Vp4 is an RNA-Capping Assembly Line. Nat.Struct.Mol.Biol., 14:449-, 2007 Cited by PubMed Abstract: Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure. PubMed: 17417654 DOI: 10.1038/NSMB1225 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation