2JHA

The structure of bluetongue virus VP4 reveals a multifunctional RNA- capping production-line

2JHA の概要

• エントリーDOI: 10.2210/pdb2jha/pdb
• 関連するPDBエントリー: 2JH9 2JHC 2JHP
• 分子名称: VP4 CORE PROTEIN, DIGUANOSINE-5'-TRIPHOSPHATE, GUANINE (3 entities in total)
• 機能のキーワード: guanylyltransferase, viral capping enzyme, core protein, virion protein, methyltransferase, viral protein
• 由来する生物種: BLUETONGUE VIRUS 10 (ISOLATE USA)
• 細胞内の位置: Virion : P07132
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 76592.37

構造登録者

Sutton, G.,Grimes, J.M.,Stuart, D.I.,Roy, P. (登録日: 2007-02-21, 公開日: 2007-04-10, 最終更新日: 2024-05-08)

主引用文献

Sutton, G.,Grimes, J.M.,Stuart, D.I.,Roy, P.
Bluetongue Virus Vp4 is an RNA-Capping Assembly Line.
Nat.Struct.Mol.Biol., 14:449-, 2007

PubMed Abstract: Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.

PubMed: 17417654
DOI: 10.1038/NSMB1225

実験手法

X-RAY DIFFRACTION (3.4 Å)