2JEK

Crystal structure of the conserved hypothetical protein Rv1873 from Mycobacterium tuberculosis at 1.38 A

Replaces:  2D2Y

Summary for 2JEK

• Entry DOI: 10.2210/pdb2jek/pdb
• Descriptor: RV1873, SULFATE ION, GLYCEROL, ... (4 entities in total)
• Functional Keywords: structural genomics, unknown function, mycobacterium tuberculosis, hypothetical protein, right-handed superhelix, tb structural genomics consortium, tbsgc, psi, protein structure initiative
• Biological source: MYCOBACTERIUM TUBERCULOSIS
• Total number of polymer chains: 1
• Total formula weight: 16507.77

Authors

Garen, C.R.,Cherney, M.M.,Bergmann, E.M.,James, M.N.G.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2007-01-17, release date: 2007-01-30, Last modification date: 2024-05-08)

Primary citation

Garen, C.R.,Cherney, M.M.,Bergmann, E.M.,James, M.N.G.
The Molecular Structure of Rv1873, a Conserved Hypothetical Protein from Mycobacterium Tuberculosis, at 1.38A Resolution
Acta Crystallogr.,Sect.F, 62:1201-, 2006

PubMed Abstract: The X-ray crystal structure of the gene product encoded by open reading frame Rv1873 of Mycobacterium tuberculosis has been determined by single isomorphous replacement with anomalous scattering (SIRAS) phasing techniques at 1.38 A resolution from monoclinic crystals with unit-cell parameters a = 33.44, b = 31.63, c = 53.19 A, beta = 90.8 degrees. The 16.2 kDa Rv1873 is a monomer that adopts a primarily alpha-helical fold with limited structural similarity to previously determined tertiary structures. It has been annotated as a conserved hypothetical protein of unknown function and is classified by the Clusters of Orthologous Groups (COG) database as belonging to COG5579. The three-dimensional structure of the Rv1873 gene product reveals limited similarity to a repeated motif that is found in a variety of other proteins. While not a novel fold, it serves as a model for orthologues predicted to be related by sequence and it is hoped that knowledge of the structure of Rv1873 will aid in determining a possible function for this protein.

PubMed: 17142896
DOI: 10.1107/S1744309106046902

Experimental method

X-RAY DIFFRACTION (1.38 Å)