2J9Q

A novel conformation for the TPR domain of pex5p

2J9Q の概要

• エントリーDOI: 10.2210/pdb2j9q/pdb
• 関連するPDBエントリー: 1FCH 2C0L 2C0M
• 分子名称: PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR, STRONTIUM ION (3 entities in total)
• 機能のキーワード: transport, zellweger syndrome, protein transport
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 72432.62

構造登録者

Stanley, W.A.,Wilmanns, M.,Kursula, P. (登録日: 2006-11-15, 公開日: 2007-04-17, 最終更新日: 2023-12-13)

主引用文献

Stanley, W.A.,Pursiainen, N.,Garman, E.F.,Juffer, A.,Wilmanns, M.,Kursula, P.
A Previously Unobserved Conformation for the Human Pex5P Receptor Suggests Roles for Intrinsic Flexibility and Rigid Domain Motions in Ligand Binding
Bmc Struct.Biol., 7:24-, 2007

PubMed Abstract: The C-terminal tetratricopeptide (TPR) repeat domain of Pex5p recognises proteins carrying a peroxisomal targeting signal type 1 (PTS1) tripeptide in their C-terminus. Previously, structural data have been obtained from the TPR domain of Pex5p in both the liganded and unliganded states, indicating a conformational change taking place upon cargo protein binding. Such a conformational change would be expected to play a major role both during PTS1 protein recognition as well as in cargo release into the peroxisomal lumen. However, little information is available on the factors that may regulate such structural changes.

PubMed: 17428317
DOI: 10.1186/1472-6807-7-24

実験手法

X-RAY DIFFRACTION (2.65 Å)