2J5Y

Crystal structure of the GA module from F.magna

2J5Y の概要

• エントリーDOI: 10.2210/pdb2j5y/pdb
• 関連するPDBエントリー: 1GAB 1PRB 1TF0
• 分子名称: PEPTOSTREPTOCOCCAL ALBUMIN-BINDING PROTEIN (2 entities in total)
• 機能のキーワード: protein binding, cell wall, peptidoglycan-anchor, protein binding bacterial albumin-binding three-helix bundle
• 由来する生物種: PEPTOSTREPTOCOCCUS MAGNUS
• 細胞内の位置: Secreted, cell wall; Peptidoglycan-anchor (Potential): Q51911
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 13639.71

構造登録者

Lejon, S.,Cramer, J.F.,Nordberg, P.A.,Lundqvist, T.,Valegard, K. (登録日: 2006-09-20, 公開日: 2007-06-26, 最終更新日: 2023-12-13)

主引用文献

Cramer, J.F.,Nordberg, P.A.,Hajdu, J.,Lejon, S.
Crystal Structure of a Bacterial Albumin-Binding Domain at 1.4A Resolution.
FEBS Lett., 581:3178-, 2007

PubMed Abstract: The albumin-binding domain, or GA module, of the peptostreptococcal albumin-binding protein expressed in pathogenic strains of Finegoldia magna is believed to be responsible for the virulence and increased growth rate of these strains. Here we present the 1.4A crystal structure of this domain, and compare it with the crystal structure of the GA-albumin complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA module is "sticky", and is capable of forming contacts with a range of protein surfaces. This might lead to interactions with different host proteins.

PubMed: 17575979
DOI: 10.1016/J.FEBSLET.2007.06.003

実験手法

X-RAY DIFFRACTION (1.4 Å)