2J3P

crystal structure of rat FGF1 at 1.4 A

2J3P の概要

• エントリーDOI: 10.2210/pdb2j3p/pdb
• 分子名称: HEPARIN-BINDING GROWTH FACTOR 1, SULFATE ION (3 entities in total)
• 機能のキーワード: growth factor, developmental protein, acidic fibroblast growth factor, differentiation, heparin-binding, mitogen, cytokine, angiogenesis, beta-trefoil
• 由来する生物種: RATTUS NORVEGICUS (RAT)
• 細胞内の位置: Secreted: P61149
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 30832.40

構造登録者

Kulahin, N.,Kristensen, O.,Berezin, V.,Gajhede, M.,Bock, E. (登録日: 2006-08-22, 公開日: 2007-02-13, 最終更新日: 2023-12-13)

主引用文献

Kulahin, N.,Kiselyov, V.,Kochoyan, A.,Kristensen, O.,Kastrup, J.S.,Berezin, V.,Bock, E.,Gajhede, M.
Structure of Rat Acidic Fibroblast Growth Factor at 1.4 A Resolution.
Acta Crystallogr.,Sect.F, 63:65-, 2007

PubMed Abstract: Fibroblast growth factors (FGFs) constitute a family of 22 structurally related heparin-binding polypeptides that are involved in the regulation of cell growth, survival, differentiation and migration. Here, a 1.4 A resolution X-ray structure of rat FGF1 is presented. Two molecules are present in the asymmetric unit of the crystal and they coordinate a total of five sulfate ions. The structures of human, bovine and newt FGF1 have been published previously. Human and rat FGF1 are found to have very similar structures.

PubMed: 17277441
DOI: 10.1107/S1744309107003144

実験手法

X-RAY DIFFRACTION (1.4 Å)