2J1V

Structure of a Streptococcus pneumoniae fucose binding module in complex with the blood group H-trisaccharide

2J1V の概要

• エントリーDOI: 10.2210/pdb2j1v/pdb
• 関連するPDBエントリー: 2J1R 2J1S 2J1T 2J1U 2J22
• 関連するBIRD辞書のPRD_ID: PRD_900036
• 分子名称: FUCOLECTIN-RELATED PROTEIN, alpha-L-fucopyranose-(1-2)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: carbohydrate-binding protein, carbohydrate binding protein
• 由来する生物種: STREPTOCOCCUS PNEUMONIAE
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34300.86

構造登録者

Boraston, A.B.,Wang, D.,Burke, R.D. (登録日: 2006-08-15, 公開日: 2006-09-06, 最終更新日: 2024-05-08)

主引用文献

Boraston, A.B.,Wang, D.,Burke, R.D.
Blood Group Antigen Recognition by a Streptococcus Pneumoniae Virulence Factor
J.Biol.Chem., 281:35263-, 2006

PubMed Abstract: The Streptococcus pneumoniae fucose utilization operon includes a gene encoding a virulence factor that belongs to family 98 in the glycoside hydrolase classification. This protein contains a C-terminal triplet of fucose binding modules that have significant amino acid sequence identity with the Anguilla anguilla fucolectin. Functional studies of these fucose binding modules reveal binding to fucosylated oligosaccharides and suggest the importance of multivalent binding. The high resolution crystal structures of ligand bound forms of one fucose binding module uncovers the molecular basis of fucose, ABH blood group antigen, and Lewisy antigen binding. These studies are extended by fluorescence microscopy to show specific binding to mouse lung tissue. These modules define a new family of carbohydrate binding modules now classified as family 47.

PubMed: 16987809
DOI: 10.1074/JBC.M607620200

実験手法

X-RAY DIFFRACTION (1.45 Å)