2IPF

Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP+ and epi-testosterone

Summary for 2IPF

Entry DOI	10.2210/pdb2ipf/pdb
Related	2IPG 2IPJ
Descriptor	(3(17)alpha-hydroxysteroid dehydrogenase), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE, ... (7 entities in total)
Functional Keywords	17a-hsd, akr1c21, akr, aldo-keto reductase, hsd, hydroxysteroid dehydrogenase, open conformation, epi-testosterone, oxidoreductase
Biological source	Mus musculus (house mouse)
Total number of polymer chains	2
Total formula weight	75560.58
Authors	Faucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Luu-the, V.,Labrie, F.,Breton, R. (deposition date: 2006-10-12, release date: 2007-06-19, Last modification date: 2023-08-30)
Primary citation	Faucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Lemieux, M.,Luu-The, V.,Labrie, F.,Breton, R. Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding. J.Mol.Biol., 369:525-540, 2007 Cited by PubMed: 17442338 DOI: 10.1016/j.jmb.2007.03.058 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation