2IPF

Crystal structure of 17alpha-hydroxysteroid dehydrogenase in complex with NADP+ and epi-testosterone

2IPF の概要

• エントリーDOI: 10.2210/pdb2ipf/pdb
• 関連するPDBエントリー: 2IPG 2IPJ
• 分子名称: (3(17)alpha-hydroxysteroid dehydrogenase), NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE, ... (7 entities in total)
• 機能のキーワード: 17a-hsd, akr1c21, akr, aldo-keto reductase, hsd, hydroxysteroid dehydrogenase, open conformation, epi-testosterone, oxidoreductase
• 由来する生物種: Mus musculus (house mouse)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 75560.58

構造登録者

Faucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Luu-the, V.,Labrie, F.,Breton, R. (登録日: 2006-10-12, 公開日: 2007-06-19, 最終更新日: 2023-08-30)

• 主引用文献: Faucher, F.,Cantin, L.,Pereira de Jesus-Tran, K.,Lemieux, M.,Luu-The, V.,Labrie, F.,Breton, R.; Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding.; J.Mol.Biol., 369:525-540, 2007; PubMed: 17442338; DOI: 10.1016/j.jmb.2007.03.058

実験手法

X-RAY DIFFRACTION (1.85 Å)