2ING

X-ray Structure of the BRCA1 BRCT mutant M1775K

2ING の概要

• エントリーDOI: 10.2210/pdb2ing/pdb
• 分子名称: Breast cancer type 1 susceptibility protein, COBALT (II) ION, SULFATE ION (3 entities in total)
• 機能のキーワード: zinc-finger, dna-binding, dna repair, disease mutation, phosphorylation, dna binding protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus . Isoform 3: Cytoplasm. Isoform 5: Cytoplasm : P38398
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24592.03

構造登録者

Birrane, G.,Soni, A.,Ladias, J.A.A. (登録日: 2006-10-07, 公開日: 2007-09-04, 最終更新日: 2023-08-30)

• 主引用文献: Tischkowitz, M.,Hamel, N.,Carvalho, M.A.,Birrane, G.,Soni, A.,van Beers, E.H.,Joosse, S.A.,Wong, N.,Novak, D.,Quenneville, L.A.,Grist, S.A.,Nederlof, P.M.,Goldgar, D.E.,Tavtigian, S.V.,Monteiro, A.N.,Ladias, J.A.,Foulkes, W.D.; Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach.; Eur.J.Hum.Genet., 16:820-832, 2008; PubMed: 18285836; DOI: 10.1038/ejhg.2008.13

実験手法

X-RAY DIFFRACTION (3.6 Å)