2IF4

Crystal structure of a multi-domain immunophilin from Arabidopsis thaliana

2IF4 の概要

• エントリーDOI: 10.2210/pdb2if4/pdb
• 関連するPDBエントリー: 2F4E
• 分子名称: ATFKBP42 (2 entities in total)
• 機能のキーワード: fkbp-like, alpha-beta, tpr-like, alpha, signaling protein
• 由来する生物種: Arabidopsis thaliana (thale cress)
• 細胞内の位置: Cell membrane; Single-pass membrane protein: Q9LDC0
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38364.39

構造登録者

Granzin, J.,Eckhoff, A.,Weiergraeber, O.H. (登録日: 2006-09-20, 公開日: 2006-10-31, 最終更新日: 2024-02-21)

主引用文献

Granzin, J.,Eckhoff, A.,Weiergraber, O.H.
Crystal Structure of a Multi-domain Immunophilin from Arabidopsis thaliana: A Paradigm for Regulation of Plant ABC Transporters.
J.Mol.Biol., 364:799-809, 2006

PubMed Abstract: FKBP42 is a membrane-anchored immunophilin playing a critical role in morphogenesis and development of higher plants. We present the X-ray structure of the cytoplasmic portion of FKBP42 comprising both the FKBP-like domain and the TPR domain at 2.85 A resolution. The data shed light on the probable binding modes of key interaction partners, including HSP90 and two classes of ABC transporters. The resulting models provide a structural background for further investigation of the unique biological properties of this protein.

PubMed: 17045295
DOI: 10.1016/j.jmb.2006.09.052

実験手法

X-RAY DIFFRACTION (2.85 Å)