2IEH

Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor that binds as (R)-enantiomer

Summary for 2IEH

Entry DOI	10.2210/pdb2ieh/pdb
Descriptor	Kinesin-like protein KIF11, MAGNESIUM ION, POTASSIUM ION, ... (8 entities in total)
Functional Keywords	beta-sheet core, flanked by three alpha-helices on each side, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P52732
Total number of polymer chains	2
Total formula weight	83697.41
Authors	Garcia-Saez, I.,Kozielski, F. (deposition date: 2006-09-19, release date: 2007-01-23, Last modification date: 2023-08-30)
Primary citation	Garcia-Saez, I.,DeBonis, S.,Lopez, R.,Trucco, F.,Rousseau, B.,Thuery, P.,Kozielski, F. Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration. J.Biol.Chem., 282:9740-9747, 2007 Cited by PubMed: 17251189 DOI: 10.1074/jbc.M608883200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation