Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor that binds as (R)-enantiomer

Summary for 2IEH

DescriptorKinesin-like protein KIF11, MAGNESIUM ION, POTASSIUM ION, ... (8 entities in total)
Functional Keywordsbeta-sheet core, flanked by three alpha-helices on each side, hydrolase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P52732
Total number of polymer chains2
Total molecular weight83697.41
Garcia-Saez, I.,Kozielski, F. (deposition date: 2006-09-19, release date: 2007-01-23, Last modification date: 2011-07-13)
Primary citation
Garcia-Saez, I.,DeBonis, S.,Lopez, R.,Trucco, F.,Rousseau, B.,Thuery, P.,Kozielski, F.
Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.
J.Biol.Chem., 282:9740-9747, 2007
PubMed: 17251189 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M608883200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.286251.1%7.9%5.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution