2IEH

Crystal structure of human kinesin Eg5 in complex with (R)-mon97, a new monastrol-based inhibitor that binds as (R)-enantiomer

2IEH の概要

• エントリーDOI: 10.2210/pdb2ieh/pdb
• 分子名称: Kinesin-like protein KIF11, MAGNESIUM ION, POTASSIUM ION, ... (8 entities in total)
• 機能のキーワード: beta-sheet core, flanked by three alpha-helices on each side, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P52732
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 83697.41

構造登録者

Garcia-Saez, I.,Kozielski, F. (登録日: 2006-09-19, 公開日: 2007-01-23, 最終更新日: 2023-08-30)

• 主引用文献: Garcia-Saez, I.,DeBonis, S.,Lopez, R.,Trucco, F.,Rousseau, B.,Thuery, P.,Kozielski, F.; Structure of human Eg5 in complex with a new monastrol-based inhibitor bound in the R configuration.; J.Biol.Chem., 282:9740-9747, 2007; PubMed: 17251189; DOI: 10.1074/jbc.M608883200

実験手法

X-RAY DIFFRACTION (2.7 Å)