2ICH

CRYSTAL STRUCTURE OF A PUTATIVE ATTH (NE1406) FROM NITROSOMONAS EUROPAEA AT 2.00 A RESOLUTION

2ICH の概要

• エントリーDOI: 10.2210/pdb2ich/pdb
• 分子名称: Putative AttH, SULFATE ION, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... (5 entities in total)
• 機能のキーワード: structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-2, lipid binding protein
• 由来する生物種: Nitrosomonas europaea
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 76493.47

構造登録者

Joint Center for Structural Genomics (JCSG) (登録日: 2006-09-12, 公開日: 2006-10-03, 最終更新日: 2024-10-30)

主引用文献

Chiu, H.J.,Bakolitsa, C.,Skerra, A.,Lomize, A.,Carlton, D.,Miller, M.D.,Krishna, S.S.,Abdubek, P.,Astakhova, T.,Axelrod, H.L.,Clayton, T.,Deller, M.C.,Duan, L.,Feuerhelm, J.,Grant, J.C.,Grzechnik, S.K.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Kozbial, P.,Kumar, A.,Marciano, D.,McMullan, D.,Morse, A.T.,Nigoghossian, E.,Okach, L.,Paulsen, J.,Reyes, R.,Rife, C.L.,van den Bedem, H.,Weekes, D.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Elsliger, M.A.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A.
Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism.
Acta Crystallogr.,Sect.F, 66:1153-1159, 2010

PubMed Abstract: The first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-terminal domain, combined with remote sequence similarity to two other protein families (PF07143 and PF08622) implicated in isoprenoid metabolism and the oxidative stress response, support an involvement in lipid metabolism. Clusters of conserved residues that interact with ligand mimetics suggest that the binding and regulation sites map to the N-terminal domain and to the interdomain interface, respectively.

PubMed: 20944205
DOI: 10.1107/S1744309109037749

実験手法

X-RAY DIFFRACTION (2 Å)