2IBL

Crystal structure of a helper molecule (HT-mf-thromb) based on mini-fibritin (mf) crystal structure (pdb:1OX3).

Summary for 2IBL

Entry DOI	10.2210/pdb2ibl/pdb
Related	1OX3
Descriptor	Fibritin (2 entities in total)
Functional Keywords	mini-fibritin, foldon, trimerization, bacteriophage t4, helper molecule, chaperone
Biological source	Enterobacteria phage T4 More
Total number of polymer chains	1
Total formula weight	14061.59
Authors	Boudko, S.P.,Rossmann, M.G. (deposition date: 2006-09-11, release date: 2007-02-27, Last modification date: 2023-08-30)
Primary citation	Boudko, S.P.,Kuhn, R.J.,Rossmann, M.G. The Coiled-coil Domain Structure of the Sin Nombre Virus Nucleocapsid Protein. J.Mol.Biol., 366:1538-1544, 2007 Cited by PubMed Abstract: Hantaviruses can cause hemorrhagic fever with a renal syndrome and hantavirus pulmonary syndrome when transmitted to humans. The nucleocapsid protein of hantaviruses encapsidates viral genomic RNA and associates with transcription and replication complexes. Both the amino and carboxy termini of the nucleocapsid protein had been predicted to form trimers prior to the formation of the ribonucleoprotein. Crystal structures of amino-terminal fragments of the nucleocapsid protein showed the formation of intramolecular antiparallel coiled coils, but not intermolecular trimers. Thus, the amino-terminal part of the nucleocapsid protein is probably insufficient to initiate the trimerization of the full-length molecule. PubMed: 17222867 DOI: 10.1016/j.jmb.2006.12.046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.32 Å)

Structure validation