2IBL

Crystal structure of a helper molecule (HT-mf-thromb) based on mini-fibritin (mf) crystal structure (pdb:1OX3).

2IBL の概要

• エントリーDOI: 10.2210/pdb2ibl/pdb
• 関連するPDBエントリー: 1OX3
• 分子名称: Fibritin (2 entities in total)
• 機能のキーワード: mini-fibritin, foldon, trimerization, bacteriophage t4, helper molecule, chaperone
• 由来する生物種: Enterobacteria phage T4; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14061.59

構造登録者

Boudko, S.P.,Rossmann, M.G. (登録日: 2006-09-11, 公開日: 2007-02-27, 最終更新日: 2023-08-30)

主引用文献

Boudko, S.P.,Kuhn, R.J.,Rossmann, M.G.
The Coiled-coil Domain Structure of the Sin Nombre Virus Nucleocapsid Protein.
J.Mol.Biol., 366:1538-1544, 2007

PubMed Abstract: Hantaviruses can cause hemorrhagic fever with a renal syndrome and hantavirus pulmonary syndrome when transmitted to humans. The nucleocapsid protein of hantaviruses encapsidates viral genomic RNA and associates with transcription and replication complexes. Both the amino and carboxy termini of the nucleocapsid protein had been predicted to form trimers prior to the formation of the ribonucleoprotein. Crystal structures of amino-terminal fragments of the nucleocapsid protein showed the formation of intramolecular antiparallel coiled coils, but not intermolecular trimers. Thus, the amino-terminal part of the nucleocapsid protein is probably insufficient to initiate the trimerization of the full-length molecule.

PubMed: 17222867
DOI: 10.1016/j.jmb.2006.12.046

実験手法

X-RAY DIFFRACTION (1.32 Å)