2I9S

The solution structure of the core of mesoderm development (MESD).

2I9S の概要

• エントリーDOI: 10.2210/pdb2i9s/pdb
• 分子名称: Mesoderm development candidate 2 (1 entity in total)
• 機能のキーワード: ferredoxin-like-fold, chaperone
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Endoplasmic reticulum: Q9ERE7
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10956.52

構造登録者

Koehler, C.,Andersen, O.,Diehl, A.,Schmieder, P.,Krause, G.,Oschkinat, H. (登録日: 2006-09-06, 公開日: 2007-05-01, 最終更新日: 2024-05-29)

主引用文献

Kohler, C.,Andersen, O.M.,Diehl, A.,Krause, G.,Schmieder, P.,Oschkinat, H.
The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family
J.STRUCT.FUNCT.GENOM., 7:131-138, 2006

PubMed Abstract: Mesoderm development (MESD) is a 224 amino acid mouse protein that acts as a molecular chaperone for receptors of the low-density lipoprotein receptor (LDLR) family. By recording (15)N-HSQC-NMR spectra of six different MESD constructs, we could determine a highly structured core region corresponding to residues 104-177. Here we firstly present the solution structure of this highly conserved core of MESD. It shows a four-stranded anti-parallel beta-sheet and two alpha-helices situated on one side of the sheet. Although described in the literature as structurally homologues to ferredoxins, the connectivity of secondary structure elements is different in the MESD fold. A structural comparison to entries of the PDB reveals a frequent domain with low sequence homology annotated as HMA and P-II domains in Pfam.

PubMed: 17342452
DOI: 10.1007/s10969-007-9016-5

実験手法

SOLUTION NMR