2I66

Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis

Summary for 2I66

• Entry DOI: 10.2210/pdb2i66/pdb
• Related: 2I65 2I67
• Descriptor: ADP-ribosyl cyclase 1, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4R,5S)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, ... (4 entities in total)
• Functional Keywords: the catalytic pocket, reaction product, reaction intermediate, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type II membrane protein: P28907
• Total number of polymer chains: 2
• Total formula weight: 63046.05

Authors

Liu, Q.,Kriksunov, I.A.,Graeff, R.,Munshi, C.,Lee, H.C.,Hao, Q. (deposition date: 2006-08-28, release date: 2006-09-05, Last modification date: 2023-08-30)

• Primary citation: Liu, Q.,Kriksunov, I.A.,Graeff, R.,Munshi, C.,Lee, H.C.,Hao, Q.; Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis.; J.Biol.Chem., 281:32861-32869, 2006; PubMed: 16951430; DOI: 10.1074/jbc.M606365200

Experimental method

X-RAY DIFFRACTION (1.7 Å)