2I66
Structural Basis for the Mechanistic Understanding Human CD38 Controlled Multiple Catalysis
Summary for 2I66
Entry DOI | 10.2210/pdb2i66/pdb |
Related | 2I65 2I67 |
Descriptor | ADP-ribosyl cyclase 1, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4R,5S)-3,4,5-TRIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, [(2R,3R,4R,5R)-5-(2-AMINO-6-OXO-1,6-DIHYDRO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | the catalytic pocket, reaction product, reaction intermediate, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type II membrane protein: P28907 |
Total number of polymer chains | 2 |
Total formula weight | 63046.05 |
Authors | Liu, Q.,Kriksunov, I.A.,Graeff, R.,Munshi, C.,Lee, H.C.,Hao, Q. (deposition date: 2006-08-28, release date: 2006-09-05, Last modification date: 2023-08-30) |
Primary citation | Liu, Q.,Kriksunov, I.A.,Graeff, R.,Munshi, C.,Lee, H.C.,Hao, Q. Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis. J.Biol.Chem., 281:32861-32869, 2006 Cited by PubMed: 16951430DOI: 10.1074/jbc.M606365200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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