2I0H

The structure of p38alpha in complex with an arylpyridazinone

2I0H の概要

• エントリーDOI: 10.2210/pdb2i0h/pdb
• 分子名称: Mitogen-activated protein kinase 14, 2-(3-{(2-CHLORO-4-FLUOROPHENYL)[1-(2-CHLOROPHENYL)-6-OXO-1,6-DIHYDROPYRIDAZIN-3-YL]AMINO}PROPYL)-1H-ISOINDOLE-1,3(2H)-DIONE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: serine/threonine kinase, inhibitor design, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43241.80

構造登録者

Natarajan, S.R.,Heller, S.T.,Nam, K.,Singh, S.B.,Scapin, G.,Patel, S.,Thompson, J.E.,Fitzgerald, C.E.,O'Keefe, S.J. (登録日: 2006-08-10, 公開日: 2006-10-17, 最終更新日: 2023-08-30)

• 主引用文献: Natarajan, S.R.,Heller, S.T.,Nam, K.,Singh, S.B.,Scapin, G.,Patel, S.,Fitzgerald, C.E.,Thompson, J.E.,O'Keefe, S.J.; p38 MAP Kinase Inhibitors Part 6: 2-Arylpyridazin-3-ones as templates for inhibitor design.; Bioorg.Med.Chem.Lett., 16:5809-5813, 2006; PubMed: 16945533; DOI: 10.1016/j.bmcl.2006.08.074

実験手法

X-RAY DIFFRACTION (2 Å)