2HX4

Rat nNOS heme domain complexed with 4-N-(Nw-nitro-L-argininyl)-trans-4-hydroxyamino-L-proline amide

2HX4 の概要

• エントリーDOI: 10.2210/pdb2hx4/pdb
• 関連するPDBエントリー: 1P6J 2HX2 2HX3
• 分子名称: Nitric-oxide synthase, ACETATE ION, ZINC ION, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase, heme enzyme, inhibitor, oxidoreductase
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100216.71

構造登録者

Igarashi, J.,Li, H.,Poulos, T.L. (登録日: 2006-08-02, 公開日: 2007-04-24, 最終更新日: 2024-02-14)

• 主引用文献: Seo, J.,Igarashi, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water.; J.Med.Chem., 50:2089-2099, 2007; PubMed: 17425297; DOI: 10.1021/jm061305c

実験手法

X-RAY DIFFRACTION (2.15 Å)