2HX3

Rat nNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine

Summary for 2HX3

Entry DOI	10.2210/pdb2hx3/pdb
Related	1P6I 2HX2 2HX4
Descriptor	Nitric-oxide synthase, ACETATE ION, ZINC ION, ... (7 entities in total)
Functional Keywords	nitric oxide synthase, heme enzyme, inhibitor, oxidoreductase
Biological source	Rattus norvegicus (Norway rat)
Cellular location	Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476
Total number of polymer chains	2
Total formula weight	100050.61
Authors	Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2006-08-02, release date: 2007-04-24, Last modification date: 2024-02-14)
Primary citation	Seo, J.,Igarashi, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem., 50:2089-2099, 2007 Cited by PubMed: 17425297 DOI: 10.1021/jm061305c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation