2HX3

Rat nNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine

Summary for 2HX3

Related1P6I 2HX2 2HX4
DescriptorNitric-oxide synthase, ACETATE ION, ZINC ION, ... (7 entities in total)
Functional Keywordsnitric oxide synthase, heme enzyme, inhibitor, oxidoreductase
Biological sourceRattus norvegicus (Norway rat)
Cellular locationCell membrane, sarcolemma; Peripheral membrane protein (By similarity) P29476
Total number of polymer chains2
Total molecular weight100050.61
Authors
Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2006-08-02, release date: 2007-04-24, Last modification date: 2011-07-13)
Primary citation
Seo, J.,Igarashi, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.
Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water.
J.Med.Chem., 50:2089-2099, 2007
PubMed: 17425297 (PDB entries with the same primary citation)
DOI: 10.1021/jm061305c
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2481202.5%4.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution