2HTT

Ruthenium Hexammine ion interactions with Z-DNA

Summary for 2HTT

• Entry DOI: 10.2210/pdb2htt/pdb
• Related: 2HTO
• Descriptor: DNA (5'-D(*DTP*DGP*DCP*DGP*DCP*DG)-3'), DNA (5'-D(*DCP*DGP*DCP*DGP*DCP*DA)-3'), DNA (5'-D(P*DTP*DG)-3'), ... (5 entities in total)
• Functional Keywords: z-dna, double helix, dna
• Total number of polymer chains: 4
• Total formula weight: 4999.56

Authors

Bharanidharan, D.,Thiyagarajan, S.,Gautham, N. (deposition date: 2006-07-26, release date: 2006-08-08, Last modification date: 2024-04-03)

Primary citation

Bharanidharan, D.,Thiyagarajan, S.,Gautham, N.
Hexammineruthenium(III) ion interactions with Z-DNA
Acta Crystallogr.,Sect.F, 63:1008-1013, 2007

PubMed Abstract: The hexamer duplex d(CGCGCA).d(TGCGCG) was crystallized with hexammineruthenium(III) ions in an orthorhombic space group; the crystals diffracted to 1.54 A resolution. Strong ion interactions with the adenine base induce a tautomeric shift from the amino to the imino form. Consequently, the A.T base pairing is disrupted. This structural study may be relevant to metal toxicity.

PubMed: 18084080
DOI: 10.1107/S1744309107047781

Experimental method

X-RAY DIFFRACTION (2.6 Å)