2HTO

Ruthenium hexammine ion interactions with Z-DNA

2HTO の概要

• エントリーDOI: 10.2210/pdb2hto/pdb
• 関連するPDBエントリー: 2HTT
• 分子名称: DNA (5'-D(*DCP*DGP*DCP*DGP*DCP*DA)-3'), DNA (5'-D(*DTP*DGP*DCP*DGP*DCP*DG)-3'), RUTHENIUM (III) HEXAAMINE ION, ... (4 entities in total)
• 機能のキーワード: z-dna, double helix, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 3822.67

構造登録者

Bharanidharan, D.,Thiyagarajan, S.,Gautham, N. (登録日: 2006-07-26, 公開日: 2006-08-08, 最終更新日: 2024-04-03)

主引用文献

Bharanidharan, D.,Thiyagarajan, S.,Gautham, N.
Hexammineruthenium(III) ion interactions with Z-DNA
Acta Crystallogr.,Sect.F, 63:1008-1013, 2007

PubMed Abstract: The hexamer duplex d(CGCGCA).d(TGCGCG) was crystallized with hexammineruthenium(III) ions in an orthorhombic space group; the crystals diffracted to 1.54 A resolution. Strong ion interactions with the adenine base induce a tautomeric shift from the amino to the imino form. Consequently, the A.T base pairing is disrupted. This structural study may be relevant to metal toxicity.

PubMed: 18084080
DOI: 10.1107/S1744309107047781

実験手法

X-RAY DIFFRACTION (1.54 Å)