2HS1

Ultra-high resolution X-ray crystal structure of HIV-1 protease V32I mutant with TMC114 (darunavir) inhibitor

Summary for 2HS1

Entry DOI	10.2210/pdb2hs1/pdb
Descriptor	HIV-1 Protease, CHLORIDE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (5 entities in total)
Functional Keywords	ultra-high resolution active site surface binding site, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22789.23
Authors	Weber, I.T.,Kovalevsky, A.Y. (deposition date: 2006-07-20, release date: 2006-10-03, Last modification date: 2024-02-14)
Primary citation	Kovalevsky, A.Y.,Liu, F.,Leshchenko, S.,Ghosh, A.K.,Louis, J.M.,Harrison, R.W.,Weber, I.T. Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114. J.Mol.Biol., 363:161-173, 2006 Cited by PubMed: 16962136 DOI: 10.1016/j.jmb.2006.08.007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (0.84 Å)

Structure validation