2HS1

Ultra-high resolution X-ray crystal structure of HIV-1 protease V32I mutant with TMC114 (darunavir) inhibitor

2HS1 の概要

• エントリーDOI: 10.2210/pdb2hs1/pdb
• 分子名称: HIV-1 Protease, CHLORIDE ION, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (5 entities in total)
• 機能のキーワード: ultra-high resolution active site surface binding site, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22789.23

構造登録者

Weber, I.T.,Kovalevsky, A.Y. (登録日: 2006-07-20, 公開日: 2006-10-03, 最終更新日: 2024-02-14)

• 主引用文献: Kovalevsky, A.Y.,Liu, F.,Leshchenko, S.,Ghosh, A.K.,Louis, J.M.,Harrison, R.W.,Weber, I.T.; Ultra-high Resolution Crystal Structure of HIV-1 Protease Mutant Reveals Two Binding Sites for Clinical Inhibitor TMC114.; J.Mol.Biol., 363:161-173, 2006; PubMed: 16962136; DOI: 10.1016/j.jmb.2006.08.007

実験手法

X-RAY DIFFRACTION (0.84 Å)