2HOB

Crystal structure of SARS-CoV main protease with authentic N and C-termini in complex with a Michael acceptor N3

Summary for 2HOB

Entry DOI	10.2210/pdb2hob/pdb
Related PRD ID	PRD_002214
Descriptor	Replicase polyprotein 1ab, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
Functional Keywords	sars-cov, main protease, michael acceptor n3, viral protein
Biological source	SARS coronavirus More
Total number of polymer chains	2
Total formula weight	34557.43
Authors	Xue, X.,Yang, H.,Shen, W.,Zhao, Q.,Li, J.,Rao, Z. (deposition date: 2006-07-14, release date: 2007-04-03, Last modification date: 2023-11-15)
Primary citation	Xue, X.,Yang, H.,Shen, W.,Zhao, Q.,Li, J.,Yang, K.,Chen, C.,Jin, Y.,Bartlam, M.,Rao, Z. Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction J.Mol.Biol., 366:965-975, 2007 Cited by PubMed: 17189639 DOI: 10.1016/j.jmb.2006.11.073 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation