2HOB
Crystal structure of SARS-CoV main protease with authentic N and C-termini in complex with a Michael acceptor N3
Summary for 2HOB
Entry DOI | 10.2210/pdb2hob/pdb |
Related PRD ID | PRD_002214 |
Descriptor | Replicase polyprotein 1ab, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total) |
Functional Keywords | sars-cov, main protease, michael acceptor n3, viral protein |
Biological source | SARS coronavirus More |
Total number of polymer chains | 2 |
Total formula weight | 34557.43 |
Authors | |
Primary citation | Xue, X.,Yang, H.,Shen, W.,Zhao, Q.,Li, J.,Yang, K.,Chen, C.,Jin, Y.,Bartlam, M.,Rao, Z. Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction J.Mol.Biol., 366:965-975, 2007 Cited by PubMed: 17189639DOI: 10.1016/j.jmb.2006.11.073 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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