2HOB

Crystal structure of SARS-CoV main protease with authentic N and C-termini in complex with a Michael acceptor N3

2HOB の概要

• エントリーDOI: 10.2210/pdb2hob/pdb
• 関連するBIRD辞書のPRD_ID: PRD_002214
• 分子名称: Replicase polyprotein 1ab, N-[(5-METHYLISOXAZOL-3-YL)CARBONYL]ALANYL-L-VALYL-N~1~-((1R,2Z)-4-(BENZYLOXY)-4-OXO-1-{[(3R)-2-OXOPYRROLIDIN-3-YL]METHYL}BUT-2-ENYL)-L-LEUCINAMIDE (3 entities in total)
• 機能のキーワード: sars-cov, main protease, michael acceptor n3, viral protein
• 由来する生物種: SARS coronavirus; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34557.43

構造登録者

Xue, X.,Yang, H.,Shen, W.,Zhao, Q.,Li, J.,Rao, Z. (登録日: 2006-07-14, 公開日: 2007-04-03, 最終更新日: 2023-11-15)

• 主引用文献: Xue, X.,Yang, H.,Shen, W.,Zhao, Q.,Li, J.,Yang, K.,Chen, C.,Jin, Y.,Bartlam, M.,Rao, Z.; Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction; J.Mol.Biol., 366:965-975, 2007; PubMed: 17189639; DOI: 10.1016/j.jmb.2006.11.073

実験手法

X-RAY DIFFRACTION (1.95 Å)