2HNC
Crystal structure of the human carbonic anhydrase II in complex with the 5-amino-1,3,4-thiadiazole-2-sulfonamide inhibitor.
Summary for 2HNC
Entry DOI | 10.2210/pdb2hnc/pdb |
Related | 1CA2 |
Descriptor | Carbonic anhydrase 2, ZINC ION, 5-AMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, ... (6 entities in total) |
Functional Keywords | protein-inhibitor complex, lyase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29909.37 |
Authors | Menchise, V.,Di Fiore, A.,De Simone, G. (deposition date: 2006-07-12, release date: 2006-12-19, Last modification date: 2023-08-30) |
Primary citation | Menchise, V.,De Simone, G.,Di Fiore, A.,Scozzafava, A.,Supuran, C.T. Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II. Bioorg.Med.Chem.Lett., 16:6204-6208, 2006 Cited by PubMed: 17000110DOI: 10.1016/j.bmcl.2006.09.022 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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