2HN7

HLA-A*1101 in complex with HBV peptide homologue

2HN7 の概要

• エントリーDOI: 10.2210/pdb2hn7/pdb
• 分子名称: HLA class I histocompatibility antigen, A-11 alpha chain, Beta-2-microglobulin, DNA polymerase PEPTIDE HOMOLOGUE, ... (5 entities in total)
• 機能のキーワード: peptide-mhc-complex, major histocompatibility complex class i, mhc-i, human leukocyte antigen, hla, immunoglobulin family, hepatitis b virus, hbv, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P13746; Secreted: P61769
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 45086.87

構造登録者

Blicher, T. (登録日: 2006-07-12, 公開日: 2006-11-28, 最終更新日: 2024-10-16)

主引用文献

Blicher, T.,Kastrup, J.S.,Pedersen, L.O.,Buus, S.,Gajhede, M.
Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue.
Acta Crystallogr.,Sect.F, 62:1179-1184, 2006

PubMed Abstract: A high-resolution structure of the human MHC-I molecule HLA-A*1101 is presented in which it forms a complex with a sequence homologue of a peptide that occurs naturally in hepatitis B virus DNA polymerase. The sequence of the bound peptide is AIMPARFYPK, while that of the corresponding natural peptide is LIMPARFYPK. The peptide does not make efficient use of the middle E pocket for binding, which leads to a rather superficial and exposed binding mode for the central peptide residues. Despite this, the peptide binds with high affinity (IC50 of 31 nM).

PubMed: 17142892
DOI: 10.1107/S1744309106044228

実験手法

X-RAY DIFFRACTION (1.6 Å)