2HLI

Solution structure of Crotonaldehyde-Derived N2-[3-Oxo-1(S)-methyl-propyl]-dG DNA Adduct in the 5'-CpG-3' Sequence

2HLI の概要

• エントリーDOI: 10.2210/pdb2hli/pdb
• 分子名称: DNA dodecamer with S-crotonaldehyde adduct, DNA dodecamer (2 entities in total)
• 機能のキーワード: interstrand dna cross-link; s-crotonaldehyde-dg adduct; 5'-cpg-3' sequence, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7396.87

構造登録者

Cho, Y.-J.,Wang, H.,Kozekov, I.D.,Kurtz, A.J.,Jacob, J.,Voehler, M.,Smith, J.,Harris, T.M.,Rizzo, C.J.,Stone, M.P. (登録日: 2006-07-07, 公開日: 2006-09-19, 最終更新日: 2018-01-31)

• 主引用文献: Cho, Y.-J.,Wang, H.,Kozekov, I.D.,Kozekova, A.,Kurtz, A.J.,Jacob, J.,Voehler, M.,Smith, J.,Harris, T.M.,Rizzo, C.J.,Lloyd, R.S.,Stone, M.P.; Orientation of the Crotonaldehyde-Derived N(2)-[3-Oxo-1(S)-methyl-propyl]-dG DNA Adduct Hinders Interstrand Cross-Link Formation in the 5'-CpG-3' Sequence; Chem.Res.Toxicol., 19:1019-1029, 2006; PubMed: 16918240; DOI: 10.1021/tx0600604

実験手法

SOLUTION NMR