2HL4

Crystal structure analysis of human carbonic anhydrase II in complex with a benzenesulfonamide derivative

2HL4 の概要

• エントリーDOI: 10.2210/pdb2hl4/pdb
• 関連するPDBエントリー: 1CA2
• 分子名称: Carbonic anhydrase 2, ZINC ION, CHLORIDE ION, ... (7 entities in total)
• 機能のキーワード: protein-inhibitor complex, lyase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30006.87

構造登録者

Di Fiore, A.,Supuran, C.T.,Winum, J.-Y.,Montero, J.-L.,Pedone, C.,Scozzafava, A.,De Simone, G. (登録日: 2006-07-06, 公開日: 2007-05-22, 最終更新日: 2023-10-25)

• 主引用文献: Di Fiore, A.,Scozzafava, A.,Winum, J.-Y.,Montero, J.-L.,Pedone, C.,Supuran, C.T.,De Simone, G.; Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties; Bioorg.Med.Chem.Lett., 17:1726-1731, 2007; PubMed: 17251017; DOI: 10.1016/j.bmcl.2006.12.099

実験手法

X-RAY DIFFRACTION (1.55 Å)