2HGF

HAIRPIN LOOP CONTAINING DOMAIN OF HEPATOCYTE GROWTH FACTOR, NMR, MINIMIZED AVERAGE STRUCTURE

2HGF の概要

• エントリーDOI: 10.2210/pdb2hgf/pdb
• 分子名称: HEPATOCYTE GROWTH FACTOR (1 entity in total)
• 機能のキーワード: hepatocyte growth factor, scatter factor, hairpin loop, heparin binding, plasminogen related, nk1
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11401.29

構造登録者

Zhou, H.,Mazzulla, M.J.,Kaufman, J.D.,Stahl, S.J.,Wingfield, P.T.,Rubin, J.S.,Bottaro, D.P.,Byrd, R.A. (登録日: 1997-12-18, 公開日: 1998-06-24, 最終更新日: 2024-10-23)

主引用文献

Zhou, H.,Mazzulla, M.J.,Kaufman, J.D.,Stahl, S.J.,Wingfield, P.T.,Rubin, J.S.,Bottaro, D.P.,Byrd, R.A.
The solution structure of the N-terminal domain of hepatocyte growth factor reveals a potential heparin-binding site.
Structure, 6:109-116, 1998

PubMed Abstract: Hepatocyte growth factor (HGF) is a multipotent growth factor that transduces a wide range of biological signals, including mitogenesis, motogenesis, and morphogenesis. The N-terminal (N) domain of HGF, containing a hairpin-loop region, is important for receptor binding and the potent biological activities of HGF. The N domain is also the primary binding site for heparin or heparan sulfate, which enhances, receptor/ligand oligomerization and modulates receptor-dependent mitogenesis. The rational design of artificial modulators of HGF signaling requires a detailed understanding of the structures of HGF and its receptor, as well as the role of heparin proteoglycan; this study represents the first step towards that goal.

PubMed: 9493272
DOI: 10.1016/S0969-2126(98)00012-4

実験手法

SOLUTION NMR