2HG2

Structure of Lactaldehyde Dehydrogenase

2HG2 の概要

• エントリーDOI: 10.2210/pdb2hg2/pdb
• 分子名称: Aldehyde dehydrogenase A, SULFATE ION (3 entities in total)
• 機能のキーワード: dehydrogenase, nad dependent, oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 52516.66

構造登録者

Di Costanzo, L.,Gomez, G.A.,Christianson, D.W. (登録日: 2006-06-26, 公開日: 2007-05-08, 最終更新日: 2024-02-14)

主引用文献

Di Costanzo, L.,Gomez, G.A.,Christianson, D.W.
Crystal structure of lactaldehyde dehydrogenase from Escherichia coli and inferences regarding substrate and cofactor specificity
J.Mol.Biol., 366:481-493, 2007

PubMed Abstract: Aldehyde dehydrogenases catalyze the oxidation of aldehyde substrates to the corresponding carboxylic acids. Lactaldehyde dehydrogenase from Escherichia coli (aldA gene product, P25553) is an NAD(+)-dependent enzyme implicated in the metabolism of l-fucose and l-rhamnose. During the heterologous expression and purification of taxadiene synthase from the Pacific yew, lactaldehyde dehydrogenase from E. coli was identified as a minor (PubMed: 17173928
DOI: 10.1016/j.jmb.2006.11.023

実験手法

X-RAY DIFFRACTION (2.2 Å)