2HB3

Wild-type HIV-1 Protease in complex with potent inhibitor GRL06579

2HB3 の概要

• エントリーDOI: 10.2210/pdb2hb3/pdb
• 分子名称: Protease, CHLORIDE ION, SODIUM ION, ... (6 entities in total)
• 機能のキーワード: active-site cavity protease inhibitor catalytic aspartic acid, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22286.49

構造登録者

Kovalevsky, A.Y.,Weber, I.T. (登録日: 2006-06-13, 公開日: 2006-08-29, 最終更新日: 2024-02-14)

• 主引用文献: Ghosh, A.K.,Sridhar, P.R.,Leshchenko, S.,Hussain, A.K.,Li, J.,Kovalevsky, A.Y.,Walters, D.E.,Wedekind, J.E.,Grum-Tokars, V.,Das, D.,Koh, Y.,Maeda, K.,Gatanaga, H.,Weber, I.T.,Mitsuya, H.; Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance.; J.Med.Chem., 49:5252-5261, 2006; PubMed: 16913714; DOI: 10.1021/jm060561m

実験手法

X-RAY DIFFRACTION (1.35 Å)