2HAQ

Crystal Structure of Cyclophilin A from Leishmania Donovani

2HAQ の概要

• エントリーDOI: 10.2210/pdb2haq/pdb
• 分子名称: Cyclophilin (2 entities in total)
• 機能のキーワード: cyclophilin, rotamase, proline, isomerase, cis-trans, protozoa, leishmania, donovani, kala-azar.
• 由来する生物種: Leishmania donovani
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19090.54

構造登録者

Venugopal, V.,Sen, B.,Datta, A.K.,Banerjee, R. (登録日: 2006-06-13, 公開日: 2006-06-20, 最終更新日: 2023-08-30)

主引用文献

Venugopal, V.,Sen, B.,Datta, A.K.,Banerjee, R.
Structure of cyclophilin from Leishmania donovani at 1.97 A resolution.
Acta Crystallogr.,Sect.F, 63:60-64, 2007

PubMed Abstract: The crystal structure of cyclophilin from Leishmania donovani (LdCyp) has been determined and refined at 1.97 A resolution to a crystallographic R factor of 0.178 (R(free) = 0.197). The structure was solved by molecular replacement using cyclophilin from Trypanosoma cruzi as the search model. LdCyp exhibits complete structural conservation of the cyclosporin-binding site with respect to the homologous human protein, as anticipated from LdCyp-cyclosporin binding studies. Comparisons with other cyclophilins show deviations primarily in the loop regions. The solvent structure encompassing the molecule has also been analyzed in some detail.

PubMed: 17277440
DOI: 10.1107/S1744309106056351

実験手法

X-RAY DIFFRACTION (1.97 Å)