2H9T

Crystal structure of human alpha-thrombin in complex with suramin

2H9T の概要

• エントリーDOI: 10.2210/pdb2h9t/pdb
• 分子名称: Thrombin, PPACK active site thrombin inhibitor, 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, ... (5 entities in total)
• 機能のキーワード: thrombin, coagulation factor ii, suramin, inhibitor, hydrolase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35593.53

構造登録者

Lima, L.M.T.R.,Polikarpov, I.,Monteiro, R.Q. (登録日: 2006-06-11, 公開日: 2007-05-22, 最終更新日: 2023-08-30)

• 主引用文献: Lima, L.M.,Becker, C.F.,Giesel, G.M.,Marques, A.F.,Cargnelutti, M.T.,de Oliveira Neto, M.,Queiroz Monteiro, R.,Verli, H.,Polikarpov, I.; Structural and thermodynamic analysis of thrombin:suramin interaction in solution and crystal phases.; Biochim.Biophys.Acta, 1794:873-881, 2009; PubMed: 19332154; DOI: 10.1016/j.bbapap.2009.03.011

実験手法

X-RAY DIFFRACTION (2.4 Å)