2H9G

Crystal structure of phage derived Fab BdF1 with human Death Receptor 5 (DR5)

2H9G の概要

• エントリーDOI: 10.2210/pdb2h9g/pdb
• 関連するPDBエントリー: 1d0g 1Za3
• 分子名称: Fab BdF1, light chain, Fab BdF1, heavy chain, Tumor necrosis factor receptor superfamily member 10B precursor, ... (4 entities in total)
• 機能のキーワード: phage display, protein engineering, combinatorial mutagenesis, antibody library, death receptor-5, agonists, immune system-apoptosis complex, immune system/apoptosis
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: O14763
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 124010.75

構造登録者

Hymowitz, S.G.,Compaan, D.M. (登録日: 2006-06-09, 公開日: 2006-08-08, 最終更新日: 2023-08-30)

• 主引用文献: Li, B.,Russell, S.J.,Compaan, D.M.,Totpal, K.,Marsters, S.A.,Ashkenazi, A.,Cochran, A.G.,Hymowitz, S.G.,Sidhu, S.S.; Activation of the Proapoptotic Death Receptor DR5 by Oligomeric Peptide and Antibody Agonists.; J.Mol.Biol., 361:522-536, 2006; PubMed: 16859704; DOI: 10.1016/j.jmb.2006.06.042

実験手法

X-RAY DIFFRACTION (2.32 Å)