2H3D

Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide

2H3D の概要

• エントリーDOI: 10.2210/pdb2h3d/pdb
• 関連するPDBエントリー: 2H3B
• 分子名称: Nicotinamide phosphoribosyltransferase, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE (3 entities in total)
• 機能のキーワード: nmn, typeii phsophoribosyltransferase, transferase
• 由来する生物種: Mus musculus (house mouse)
• 細胞内の位置: Cytoplasm: Q99KQ4
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 112465.94

構造登録者

Wang, T.,Zhang, X.,Bheda, P.,Revollo, J.R.,Imai, S.I.,Wolberger, C. (登録日: 2006-05-22, 公開日: 2006-06-20, 最終更新日: 2024-10-16)

主引用文献

Wang, T.,Zhang, X.,Bheda, P.,Revollo, J.R.,Imai, S.I.,Wolberger, C.
Structure of Nampt/PBEF/visfatin, a mammalian NAD(+) biosynthetic enzyme.
Nat.Struct.Mol.Biol., 13:661-662, 2006

PubMed Abstract: Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.

PubMed: 16783373
DOI: 10.1038/nsmb1114

実験手法

X-RAY DIFFRACTION (2.1 Å)