2H32

Crystal structure of the pre-B cell receptor

2H32 の概要

• エントリーDOI: 10.2210/pdb2h32/pdb
• 分子名称: Immunoglobulin iota chain, Immunoglobulin omega chain, Immunoglobulin heavy chain, ... (5 entities in total)
• 機能のキーワード: beta sheets, v and c-type ig folds, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 52308.18

構造登録者

Bankovich, A.J. (登録日: 2006-05-22, 公開日: 2007-04-24, 最終更新日: 2023-08-30)

主引用文献

Bankovich, A.J.,Raunser, S.,Juo, Z.S.,Walz, T.,Davis, M.M.,Garcia, K.C.
Structural Insight into Pre-B Cell Receptor Function
Science, 316:291-294, 2007

PubMed Abstract: The pre-B cell receptor (pre-BCR) serves as a checkpoint in B cell development. In the 2.7 angstrom structure of a human pre-BCR Fab-like fragment, consisting of an antibody heavy chain (HC) paired with the surrogate light chain, the "unique regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an antibody light chain and appear to "probe" the HC CDR3, potentially influencing the selection of the antibody repertoire. Biochemical analysis indicates that the pre-BCR is impaired in its ability to recognize antigen, which, together with electron microscopic visualization of a pre-BCR dimer, suggests ligand-independent oligomerization as the likely signaling mechanism.

PubMed: 17431183
DOI: 10.1126/science.1139412

実験手法

X-RAY DIFFRACTION (2.7 Å)