2H2Z

Crystal structure of SARS-CoV main protease with authentic N and C-termini

Summary for 2H2Z

• Entry DOI: 10.2210/pdb2h2z/pdb
• Descriptor: Replicase polyprotein 1ab (2 entities in total)
• Functional Keywords: sars, main protease, authentic n and c termini, viral protein
• Biological source: SARS coronavirus
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• Total number of polymer chains: 1
• Total formula weight: 33876.64

Authors

Yang, H.,Xue, X.,Shen, W.,Zhao, Q.,Rao, Z. (deposition date: 2006-05-20, release date: 2007-04-03, Last modification date: 2024-03-13)

• Primary citation: Xue, X.,Yang, H.,Shen, W.,Zhao, Q.,Li, J.,Yang, K.,Chen, C.,Jin, Y.,Bartlam, M.,Rao, Z.; Production of authentic SARS-CoV M(pro) with enhanced activity: application as a novel tag-cleavage endopeptidase for protein overproduction; J.Mol.Biol., 366:965-975, 2007; PubMed: 17189639; DOI: 10.1016/j.jmb.2006.11.073

Experimental method

X-RAY DIFFRACTION (1.6 Å)