2GZQ

Phosphatidylethanolamine-binding protein from Plasmodium vivax

2GZQ の概要

• エントリーDOI: 10.2210/pdb2gzq/pdb
• 分子名称: Phosphatidylethanolamine-binding protein (2 entities in total)
• 機能のキーワード: structural genomics, psi, protein structure initiative, structural genomics of pathogenic protozoa consortium, sgpp, lipid binding protein
• 由来する生物種: Plasmodium vivax (malaria parasite P. vivax)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23298.71

構造登録者

Arakaki, T.L.,Merritt, E.A.,Structural Genomics of Pathogenic Protozoa Consortium (SGPP) (登録日: 2006-05-11, 公開日: 2006-05-23, 最終更新日: 2024-11-20)

主引用文献

Arakaki, T.,Neely, H.,Boni, E.,Mueller, N.,Buckner, F.S.,Van Voorhis, W.C.,Lauricella, A.,DeTitta, G.,Luft, J.,Hol, W.G.,Merritt, E.A.
The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix
Acta Crystallogr.,Sect.F, 63:178-182, 2007

PubMed Abstract: The structure of a putative Raf kinase inhibitor protein (RKIP) homolog from the eukaryotic parasite Plasmodium vivax has been studied to a resolution of 1.3 A using multiple-wavelength anomalous diffraction at the Se K edge. This protozoan protein is topologically similar to previously studied members of the phosphatidylethanolamine-binding protein (PEBP) sequence family, but exhibits a distinctive left-handed alpha-helical region at one side of the canonical phospholipid-binding site. Re-examination of previously determined PEBP structures suggests that the P. vivax protein and yeast carboxypeptidase Y inhibitor may represent a structurally distinct subfamily of the diverse PEBP-sequence family.

PubMed: 17329808
DOI: 10.1107/S1744309107007580

実験手法

X-RAY DIFFRACTION (1.3 Å)