2GZ9
Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of SARS-CoV Main Protease
2GZ9 の概要
エントリーDOI | 10.2210/pdb2gz9/pdb |
関連するPDBエントリー | 2GZ7 2GZ8 |
分子名称 | Replicase polyprotein 1ab (2 entities in total) |
機能のキーワード | sars cov main protease, hydrolase |
由来する生物種 | SARS coronavirus |
細胞内の位置 | Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 33876.64 |
構造登録者 | |
主引用文献 | Lu, I.L.,Mahindroo, N.,Liang, P.H.,Peng, Y.H.,Kuo, C.J.,Tsai, K.C.,Hsieh, H.P.,Chao, Y.S.,Wu, S.Y. Structure-Based Drug Design and Structural Biology Study of Novel Nonpeptide Inhibitors of Severe Acute Respiratory Syndrome Coronavirus Main Protease J.Med.Chem., 49:5154-5161, 2006 Cited by PubMed: 16913704DOI: 10.1021/jm060207o 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.17 Å) |
構造検証レポート
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